Cholesterol-lowering Medicines

Lowering your “bad” cholesterol can reduce your risk of having a heart attack or stroke. “Bad” cholesterol is also called LDL, or low-density lipoprotein. A number of lifestyle changes can help you improve your cholesterol level. Your doctor may ask you try these changes for 6 months to 1 year. If they don’t help, your doctor may prescribe medicine to lower your cholesterol.

Path to improved health

Even if you take cholesterol-lowering medicine, it’s important to keep up with your lifestyle changes. Eating healthy and being physically active can make your medicine more effective. Your doctor can give you tips on how to make healthy food choices. He or she can also suggest how to include physical activity in your daily routine.

What are some common cholesterol-lowering medicines?

Several types of medicine are used to treat high cholesterol levels. Your doctor will decide which type of medicine is right for you. He or she may prescribe more than 1 of these drugs at a time.

  • Statins (also called HMG-CoA reductase inhibitors) slow down your body’s production of cholesterol. These drugs also remove cholesterol buildup from your arteries (blood vessels).
  • Resins (also called bile acid sequestrants) bind to bile acids. Bile acids help with digestion. They are made by your liver using cholesterol. When resins bind to the bile, the body gets rid of them. This prompts your body to use excess cholesterol to make more bile acids. This lowers your LDL cholesterol level.
  • Cholesterol absorption inhibitors reduce the amount of cholesterol that is absorbed by your intestines. This type of medicine is often prescribed in combination with a statin.
  • Fibrates help lower your cholesterol by reducing the amount of triglycerides (fats) in your body. Fibrates are also called fibric acid derivatives. They also increase your level of “good” cholesterol (also called HDL, or high-density lipoprotein).

Things to consider

Like all medicines, these drugs can cause side effects. However, the side effects usually are not severe. They also are not experienced very often.

Common side effects of cholesterol-lowering drugs include the following:

  • diarrhea or constipation
  • abdominal pain, cramps, bloating,or gas
  • nausea
  • vomiting
  • headache
  • drowsiness
  • dizziness
  • muscle aches or weakness
  • flushing (skin turning red and warm)
  • sleep problems.

Tell your doctor as soon as possible if your side effects become severe.

What is a drug interaction?

If you take 2 or more medicines at the same time, the way your body processes each drug can change. When this happens, the risk of side effects from each drug increases. Plus, each drug may not work the way it should. This is called a “drug-drug interaction.” Vitamins and herbal supplements can also affect the way your body processes medicine.

Certain foods or drinks can also prevent your medicine from working the way it should. They can also make side effects worse. This is called a “drug-food interaction.”

Drug-drug interactions and drug-food interactions can be dangerous. Be certain that your doctor knows everything you are taking. This includes all over-the-counter and prescription medicines, vitamins, and herbal supplements. And don’t start taking any new medicines without first talking to your doctor. This includes any new over-the-counter or prescription medicine, vitamin, or herbal supplement.

It’s important to take medicines exactly as your doctor tells you to. Ask your doctor whether you need to avoid any foods or drinks while using your cholesterol-lowering medicine.

Questions for your doctor

  • How often should I have my cholesterol checked?
  • What kind of side effects may I have while taking the medicine?
  • What if I miss a dose of the medicine?
  • Does taking this medicine mean that I can eat whatever I want?
  • Do I need to also limit salt in my diet for heart health?
  • Can I drink alcohol while taking this medicine?
  • Will I always have to take medicine to lower my cholesterol?

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